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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
24.85
Human Site:
S140
Identified Species:
39.05
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
S140
T
D
K
Y
R
T
Y
S
K
K
H
F
R
I
F
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
S140
T
D
K
Y
R
T
Y
S
K
K
H
F
R
I
F
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
S140
T
D
K
Y
R
T
Y
S
K
K
H
F
R
I
F
Dog
Lupus familis
XP_543464
544
61233
S141
T
D
K
Y
R
T
Y
S
K
K
H
F
R
I
F
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
S144
T
D
K
Y
R
T
Y
S
K
K
H
F
R
I
F
Rat
Rattus norvegicus
NP_446129
545
60912
S143
T
D
K
Y
R
T
Y
S
K
K
H
F
R
I
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
S133
R
E
L
G
P
K
S
S
Y
I
T
Y
I
E
D
Chicken
Gallus gallus
NP_001073576
522
58779
I137
K
N
S
Y
V
A
Y
I
E
D
H
S
A
N
G
Frog
Xenopus laevis
NP_001082016
517
58243
N131
H
G
H
S
R
V
A
N
I
E
D
L
S
G
N
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
A58
Q
G
Q
S
Q
A
V
A
K
V
S
Q
S
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
Y113
C
E
L
T
N
P
V
Y
I
Q
D
L
S
R
N
Honey Bee
Apis mellifera
XP_624334
480
54300
G116
Q
N
G
T
F
V
N
G
K
K
V
G
R
G
N
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
H113
E
T
R
R
I
Y
L
H
D
H
S
R
N
G
T
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
H116
Y
Q
T
L
S
K
T
H
F
R
I
F
K
E
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
S130
D
R
I
V
F
G
K
S
C
S
F
L
F
K
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
20
6.6
6.6
N.A.
0
20
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
33.3
20
26.6
N.A.
13.3
26.6
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
14
7
7
0
0
0
0
7
0
0
% A
% Cys:
7
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
7
40
0
0
0
0
0
0
7
7
14
0
0
0
7
% D
% Glu:
7
14
0
0
0
0
0
0
7
7
0
0
0
14
0
% E
% Phe:
0
0
0
0
14
0
0
0
7
0
7
47
7
0
40
% F
% Gly:
0
14
7
7
0
7
0
7
0
0
0
7
0
20
7
% G
% His:
7
0
7
0
0
0
0
14
0
7
47
0
0
0
0
% H
% Ile:
0
0
7
0
7
0
0
7
14
7
7
0
7
40
0
% I
% Lys:
7
0
40
0
0
14
7
0
54
47
0
0
7
7
0
% K
% Leu:
0
0
14
7
0
0
7
0
0
0
0
20
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
14
0
0
7
0
7
7
0
0
0
0
7
7
20
% N
% Pro:
0
0
0
0
7
7
0
0
0
0
0
0
0
7
7
% P
% Gln:
14
7
7
0
7
0
0
0
0
7
0
7
0
0
0
% Q
% Arg:
7
7
7
7
47
0
0
0
0
7
0
7
47
7
0
% R
% Ser:
0
0
7
14
7
0
7
54
0
7
14
7
20
0
7
% S
% Thr:
40
7
7
14
0
40
7
0
0
0
7
0
0
0
7
% T
% Val:
0
0
0
7
7
14
14
0
0
7
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
47
0
7
47
7
7
0
0
7
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _